Main refers to the ISCHEMIA trial. CKD refers to the ISCHEMIA-CKD trial. A) All-cause Death (Primary MI Definition); B) All-cause Death (Secondary MI Definition). Top Panel: The cumulative incidence of all-cause death was greater in patients that had a type 1 MI compared with those that did not during follow-up in both trials regardless of MI definition used. The higher risk population in the ISCHEMIA-CKD trial is illustrated by the fact that the cumulative incidence of death in patients without an MI during follow-up exceeded that observed in the ISCHEMIA population with a type 1 MI.
Bottom Panel: The cumulative incidence of all-cause death after procedural MI was greater compared with those that did not have an MI during follow-up, regardless of MI definition used. In contrast, in the ISCHEMIA trial which enrolled a lower-risk population, the cumulative incidence of all-cause death after procedural MI was similar compared with those that did not have an MI during follow-up, regardless of MI definition used.