Table 1:
Cumulative Incidence Rates and Hazard Ratios for MI Types: Primary MI Definition
| MI type* | INV (N=388) | CON (N=389) | Adjusted† Hazard Ratio (95% CI) | P-value |
|---|---|---|---|---|
| Overall Definition | 0.84 (0.56, 1.24) | 0.372 | ||
| Number of Events | 46 | 56 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | 3.39% (1.90%, 5.55%) | 4.12% (2.46%, 6.44%) | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 3.91% (2.29%, 6.20%) | 5.16% (3.26%, 7.68%) | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 6.34% (4.18%, 9.10%) | 8.26% (5.79%, 11.28%) | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 9.90% (7.09%, 13.26%) | 12.55% (9.41%, 16.16%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 15.04% (10.94%, 19.75%) | 15.92% (12.09%, 20.22%) | ||
| Type 1 | 0.64 (0.37, 1.09) | 0.098 | ||
| Number of Events | 22 | 35 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | 1.30% (0.50%, 2.87%) | 3.09% (1.69%, 5.18%) | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 1.30% (0.50%, 2.87%) | 3.87% (2.26%, 6.13%) | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 2.92% (1.55%, 5.00%) | 5.94% (3.88%, 8.60%) | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 4.73% (2.86%, 7.29%) | 8.03% (5.54%, 11.10%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 7.77% (4.81%, 11.65%) | 8.99% (6.24%, 12.35%) | ||
| Type 2 | 0.64 (0.32, 1.30) | 0.215 | ||
| Number of Events | 13 | 20 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | 0.26% (0.03%, 1.38%) | 0.77% (0.22%, 2.12%) | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 0.26% (0.03%, 1.38%) | 1.03% (0.35%, 2.48%) | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 1.34% (0.51%, 2.95%) | 1.55% (0.65%, 3.19%) | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 2.81% (1.44%, 4.93%) | 4.57% (2.76%, 7.04%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 3.93% (2.05%, 6.77%) | 6.02% (3.73%, 9.05%) | ||
| Type 1,2 | 0.66 (0.42, 1.02) | 0.061 | ||
| Number of Events | 33 | 50 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | 1.56% (0.65%, 3.22%) | 3.87% (2.26%, 6.13%) | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 1.56% (0.65%, 3.22%) | 4.90% (3.05%, 7.37%) | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 3.72% (2.13%, 5.99%) | 7.23% (4.93%, 10.10%) | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 7.00% (4.65%, 9.98%) | 11.13% (8.19%, 14.56%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 11.17% (7.57%, 15.54%) | 13.56% (10.07%, 17.57%) | ||
| Type 4a | 6.95 (0.75, 64.75) | 0.088 | ||
| Number of Events | 5 | 1 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | 1.30% (0.50%, 2.87%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 1.30% (0.50%, 2.87%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 1.30% (0.50%, 2.87%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 1.30% (0.50%, 2.87%) | 0.27% (0.03%, 1.41%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 1.30% (0.50%, 2.87%) | 0.27% (0.03%, 1.41%) | ||
| Type 4b | 2.97 (0.37, 23.91) | 0.307 | ||
| Number of Events | 3 | 2 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | --- | 0.26% (0.03%, 1.37%) | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 0.26% (0.03%, 1.39%) | 0.26% (0.03%, 1.37%) | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 0.26% (0.03%, 1.39%) | 0.52% (0.11%, 1.75%) | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 0.26% (0.03%, 1.39%) | 0.52% (0.11%, 1.75%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 1.30% (0.34%, 3.64%) | 0.52% (0.11%, 1.75%) | ||
| Type 4c | 3.76 (0.38, 36.94) | 0.255 | ||
| Number of Events | 4 | 1 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | --- | --- | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 0.52% (0.11%, 1.77%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 1.07% (0.36%, 2.56%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 1.07% (0.36%, 2.56%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 1.07% (0.36%, 2.56%) | 0.43% (0.04%, 2.21%) | ||
| Type 4b/c | 2.32 (0.57, 9.40) | 0.237 | ||
| Number of Events | 6 | 3 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | --- | 0.26% (0.03%, 1.37%) | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 0.79% (0.22%, 2.15%) | 0.26% (0.03%, 1.37%) | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 1.06% (0.36%, 2.54%) | 0.52% (0.11%, 1.75%) | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 1.06% (0.36%, 2.54%) | 0.52% (0.11%, 1.75%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 2.09% (0.82%, 4.45%) | 0.94% (0.25%, 2.64%) | ||
| Type 5 | 0.81 (0.13, 4.96) | 0.816 | ||
| Number of Events | 2 | 3 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | 0.52% (0.11%, 1.76%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 0.52% (0.11%, 1.76%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 0.52% (0.11%, 1.76%) | 0.52% (0.11%, 1.75%) | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 0.52% (0.11%, 1.76%) | 0.83% (0.23%, 2.28%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 0.52% (0.11%, 1.76%) | 0.83% (0.23%, 2.28%) | ||
| Procedural (Type 4a/5) | 2.04 (0.59, 7.08) | 0.259 | ||
| Number of Events | 7 | 4 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | 1.82% (0.81%, 3.57%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | 1.82% (0.81%, 3.57%) | --- | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | 1.82% (0.81%, 3.57%) | 0.52% (0.11%, 1.75%) | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 1.82% (0.81%, 3.57%) | 1.10% (0.37%, 2.64%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 1.82% (0.81%, 3.57%) | 1.10% (0.37%, 2.64%) | ||
| Silent/Unrecognized | 0.61 (0.09, 3.86) | 0.595 | ||
| Number of Events | 2 | 3 | ||
| Cumulative Incidence Rate (95% CI) at 3 Months | --- | --- | ||
| Cumulative Incidence Rate (95% CI) at 6 Months | --- | --- | ||
| Cumulative Incidence Rate (95% CI) at 1 Year | --- | --- | ||
| Cumulative Incidence Rate (95% CI) at 2 Years | 0.56% (0.11%, 1.88%) | 0.64% (0.13%, 2.17%) | ||
| Cumulative Incidence Rate (95% CI) at 3 Years | 0.56% (0.11%, 1.88%) | 1.14% (0.30%, 3.15%) |
*
Each MI type is analyzed based on the time to the first event for that type. No MI events were Type 3.
†
Hazard ratios compare INV vs. CON. The covariates used for adjustment include age, sex, eGFR, ejection fraction, diabetes and dialysis. Missing values are imputed through multiple imputation. Continuous variables are modeled as restricted cubic splines.