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Resident enteric bacteria are required for colon inflammation in IL-10-deficient mice. Representative photomicrographs from the middle colon of (a) an IL-10-deficient SPF mouse, (b) an IL-10-deficient germfree mouse, and (c) a wild-type SPF mouse. Note the marked mucosal hyperplasia, lamina propria cellular infiltrates, and crypt abscess (arrow) shown in panel a that are absent in panels b and c. Magnification, ×58.
