TABLE 2.
Parameter estimates with 95% credible intervals (low, high) regarding hazard rates over time for the stable-to-progression transition, the stable-to-death transition, and progression-to-death transition with treatment 1 for a selection of alternative meta-analysis models.
| Model 1 |
Model 2 |
Model 3 |
Model 4 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Estimate | Low | High | Estimate | Low | High | Estimate | Low | High | Estimate | Low | High |
| M 1 | −3.752 | −4.081 | −3.512 | −3.758 | −4.102 | −3.514 | −3.628 | −3.777 | −3.469 | −3.136 | −3.23 | −3.041 |
| M 2 | 0.974 | 0.768 | 1.241 | 0.963 | 0.761 | 1.237 | 0.512 | 0.441 | 0.583 | 0.052 | 0.044 | 0.06 |
| M 3 | −0.073 | −0.101 | −0.049 | −0.069 | −0.098 | −0.046 | ||||||
| M 4 | −4.786 | −5.306 | −4.378 | −4.808 | −5.34 | −4.385 | −4.587 | −4.605 | −4.513 | −4.589 | −4.605 | −4.527 |
| M 5 | −0.984 | −1.17 | −0.578 | −0.992 | −1.17 | −0.615 | 0.013 | −0.013 | 0.07 | |||
| M 6 | −2.983 | −3.431 | −2.504 | −2.779 | −2.872 | −2.681 | −2.968 | −3.059 | −2.879 | −2.97 | −3.053 | −2.881 |
| M 7 | 0.071 | −0.092 | 0.227 | |||||||||
Note: Model 1: SP second order FP(01); SD Weibull; PD Weibull. Model 2: SP second order FP(01); SD Weibull; PD exponential. Model 3: SP Weibull; SD Weibull; PD exponential. Model 4: SP Gompertz; SD exponential; PD exponential. Estimate: the median of the posterior distribution; low and high: lower and upper bound of the 95% credible interval corresponding to the 2.5 th and 97.5 th percentile of the posterior distribution.