. Author manuscript; available in PMC: 2024 Feb 14.

Published in final edited form as: Stat Med. 2023 Jun 10;42(19):3371–3391. doi: 10.1002/sim.9810

TABLE 3.

Relative treatment effect parameter estimates with 95% credible intervals (low, high) regarding time-varying hazard rates for the stable-to-progression transition, stable-to-death transition, and progression-to-death transition for a selection of alternative network meta-analysis models.

	Model 1			Model 2			Model 3			Model 4
Parameter	Estimate	Low	High	Estimate	Low	High	Estimate	Low	High	Estimate	Low	High
d _1,11	0	0	0	0	0	0	0	0	0	0	0	0
d _1,12	−0.661	−1.686	0.286	−0.483	−1.299	0.299	−0.481	−1.013	0	−0.531	−1.1	−0.048
d _1,13	−0.096	−0.904	0.709	−0.131	−0.74	0.485	−0.069	−0.36	0.237	−0.14	−0.433	0.17
d _1,14	0.222	−1.019	1.389	−0.019	−0.981	0.977	0.016	−0.41	0.445	0.042	−0.388	0.457
d _1,15	0.7	0.137	1.254	0.636	0.208	1.056	0.685	0.449	0.932	0.689	0.459	0.918
d _2,11	0	0	0	0	0	0	0	0	0	0	0	0
d _2,12	−0.84	−1.635	−0.114	−0.152	−0.411	0.127	−0.085	−0.349	0.187	−0.019	−0.283	0.262
d _2,13	−0.206	−0.645	0.169	−0.059	−0.209	0.089	−0.074	−0.227	0.074	−0.045	−0.199	0.101
d _2,14	−0.547	−1.089	−0.013	−0.341	−0.535	−0.135	−0.347	−0.539	−0.156	−0.344	−0.536	−0.15
d _2,15	0.127	−0.256	0.492	0.122	−0.005	0.249	0.156	0.026	0.28	0.084	−0.035	0.209
d _3,11	0	0	0
d _3,12	0.217	0.053	0.388
d _3,13	0.024	−0.028	0.079
d _3,14	0.029	−0.042	0.096
d _3,15	−0.021	−0.093	0.049
d _4,11	0	0	0	0	0	0	0	0	0
d _4,12	−0.114	−0.997	0.37	0.339	0.003	0.696	0.046	−0.462	0.503
d _4,13	−0.041	−0.273	0.181	0.051	−0.135	0.247	−0.134	−0.333	0.074
d _4,14	0.24	−0.094	0.564	0.146	−0.18	0.48	0.207	−0.105	0.516
d _4,15	−0.245	−0.393	−0.095	−0.299	−0.45	−0.148	−0.273	−0.43	−0.112
$σ_{d_{1}}$	0.445	0.237	0.891	0.372	0.211	0.749

Note: Model 1: SP second order FP(01) RE3; SD Weibull; PD Weibull FE1(scale). Model 2: SP Weibull RE2; SD exponential; PD Weibull FE1(scale). Model 3: SP Weibull FE2; SD Weibull; PD exponential FE. Model 4: SP Weibull FE2; SD exponential; PD exponential. Estimate: the median of the posterior distribution. Low and high: lower and upper bound of the 95% credible interval corresponding to the 2.5th and 97.5th percentile of the posterior distribution. $d_{1, 1 t}$ : relative treatment effect with treatment $t$ versus treatment 1 regarding the scale of the log-hazard function describing the stable-to-progression transition. $d_{2, 1 t}$ : relative treatment effect with treatment $t$ versus treatment 1 regarding the first shape parameter of the log-hazard function describing the stable-to-progression transition. $d_{3, 1 t}$ : relative treatment effect with treatment $t$ versus treatment 1 regarding the second shape parameter of the log-hazard function describing the stable-to-progression transition. $d_{4, 1 t}$ : relative treatment effect with treatment $t$ versus treatment 1 regarding the scale of the log-hazard function describing the progression-to-death transition.