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. 2014 Mar 18;2014(3):CD006930. doi: 10.1002/14651858.CD006930.pub3

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Trial sequential analysis of hospital stay 
 The diversity‐adjusted required information size (DARIS) was 183 participants based on a minimal relevant difference (MIRD) of one day, a variance (VAR) of 0.47, an alpha (a) of 5%, a beta (b) of 20%, and a diversity (D2) of 91.83%. Neither the conventional statistical boundaries (dotted red line) nor the trial sequential monitoring boundaries (red line) are crossed by the cumulative Z‐curve (blue line), although the DARIS has been reached. The findings are consistent with no significant difference in length of hospital stay between low pressure and standard pressure pneumoperitoneum with low risk of random errors.