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. 2014 Mar 18;2014(3):CD006930. doi: 10.1002/14651858.CD006930.pub3

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Trial sequential analysis of operating time 
 The diversity‐adjusted required information size (DARIS) was 37 participants based on a minimal relevant difference (MIRD) of 15 minutes, a variance (VAR) of 258.34, an alpha (a) of 5%, a beta (b) of 20%, and a diversity (D2) of 0%. The conventional statistical boundaries (dotted red line) are crossed by the cumulative Z‐curve (blue line) after the fourth trial. The trial sequential monitoring boundary (red line) is crossed by the cumulative Z‐curve after the second trial. The findings are consistent with low pressure pneumoperitoneum associated with a longer operating time than standard pressure pneumoperitoneum with low risk of random errors.