FIGURE 4.

Pearson's correlation analysis of Ng and humanized anti‐ASC (IC100) in the hippocampal subfields. An example of double‐labeling immunostaining of Ng (green) and 1C100 (red) of controls (A) in intermediate AD (B). In the controls, the correlation analysis did not reveal any significant relationship between the number of Ng positive neurons and the number of IC100 ‐positive neurons (C, and E). The intermediate AD cases showed a significant negative correlation between Ng and IC100 in the CA1 (D), and the CA2 (F) hippocampal regions. AD, Alzheimer's disease; ASC, apoptosis‐associated speck‐like protein containing a caspase recruitment domain; CA, cornu ammonis; Ng, neurogranin. Scale bars = 30 μm (A) and (B)