TABLE 1.

MAP2 immunopositive neurons.

Region	Control	Intermediate AD	P value	Significance
Entorhinal cortex	299 ± 81	161 ± 84	0.013	*
Subiculum	253 ± 57	199 ± 28	0.3	ns
CA1	196 ± 20	123 ± 19	0.02	*
CA2	260 ± 32	146 ± 21	0.009	**
CA3	278 ± 32	140 ± 20	0.005	**
Dentate gyrus	238 ± 23	219 ± 63	0.41	ns
Ng immunopositive neurons

Region	Control	Intermediate AD	P value	Significance
Entorhinal cortex	225 ± 20	149 ± 22	0.016	*
Subiculum	269 ± 63	207 ± 54	0.08	*
CA1	149 ± 36	112 ± 42	0.02	*
CA2	223 ± 60	104 ± 45	<0.0001	***
CA3	296 ± 17	104 ± 12	<0.0001	***
Dentate gyrus	233 ± 49	218 ± 61	0.43	ns

Note. t test for each ROI, mean ± SD, P value, and significance. Counts are expressed as MAP2‐ or Ng‐positive neurons in 1 mm² area in AD cases and in controls.

Abbreviations: AD, Alzheimer's disease; CA, cornu ammonis; MAP2, microtubule‐associated proteins type II; Ng, neurogranin; ns, not significant; ROI, region of interest; SD, standard deviation.

^* P < 0.05.

^** P < 0.01.

^*** P < 0.001.