FIGURE 4.

Secondary endpoints. Scores on the Functional Activities Questionnaire (FAQ; A, B, and C), Mini‐Mental Status Exam (MMSE; D, E, and F), and Lure Discrimination Index (LDI) from the Behavioral Pattern Separation‐Objects (BPS‐O) Task served as secondary endpoints in this study. For FAQ higher scores indicate greater impairment, while higher scores on the MMSE, and BPS‐O indicate better performance. Graphs show progression of scores over the 78‐week treatment period for both the placebo and AGB101 groups for the intention‐to‐treat population (A, D, and G), and by apolipoprotein E (ApoE)‐4 carrier status showing longitudinal change in secondary endpoints for ApoE‐4 noncarriers (B, E, and H) and ApoE‐4 carriers (C, F, and I). Values represent sample means ± SEM