Fig. 5.

Foreign body reaction after 6-week implantation. A H&E slices for sham surgery (left), soft cuff (middle) and fixed cuff (right). B MBP, Tuj1 and DAPI staining of same implantation groups, illustrated in correspondence of both peroneal (P) and tibial (T) regions. C Proportion of total nerve area occupied by extrafascicular tissue. D Blood vessel count in different groups, highlighting increased vascularization in extrafascicular areas. E Quantification of myelin density in tibial and peroneal regions. Statistics: Wilcoxon rank sum test for * adjusted p < 0.05, with Bonferroni correction for multiple comparisons