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. 2024 Jan 17;15(2):e02867-23. doi: 10.1128/mbio.02867-23

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Fig 5 — Proksee alignment to pLVPK: 29 strains with a closed plasmid harboring any virulence biomarker were compared to the canonical pLVPK. Alignment of the pLVPK sequence to all closed pLVPK-like plasmid sequences from (A) hvKp (n = 9) and (B) cKp isolates (n = 20) were produced with Proksee. Virulence and landmark genes from pLVPK are labeled in each panel. The five virulence biomarkers of interest are concentrated on a roughly 30 kb region of pLVPK from iucA to iroB. Concentric circles are sorted by alignment fraction to pLVPK sequence with the outermost ring representing the isolate with the highest alignment fraction. The average alignment fraction of pLVPK-like plasmid to pLVPK is higher in hvKp isolates compared to cKp. Alignment covering the virulence biomarkers is more extensive in hvKp isolates. Most cKp isolates lack or have non-functioning iroB, peg-344, and rmpA while possessing a rmpA2 and iucA.