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. 2024 Jan 23;15(2):e01898-23. doi: 10.1128/mbio.01898-23

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Copyright © 2024 Avelar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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Fig 2 — Impact of lactate and hypoxia on the transcriptomes of responsive and non-responsive C. albicans clinical isolates. RNA sequencing was performed on five responsive (CEC3560, CEC3605, CEC3609, CEC4108, and CEC4259) and five non-responsive clinical isolates (CEC3534, CEC3544, CEC3621, CEC3636, and CEC4035) following exposure to lactate or hypoxia for 1 hour and compared to the control condition (fresh GYNB for 1 hour). (A) Venn diagram showing the numbers of genes that were upregulated (>twofold) in the responsive isolates in response to lactate and hypoxia. Seven genes that were significantly upregulated under both β-1,3-glucan masking conditions are shown. (B) Gene ontology terms that were significantly enriched in the gene sets that were upregulated in the responsive isolates in response to lactate and hypoxia. The degree of statistical significance of this enrichment is indicated by the color coding.