TABLE 1.
Metadata on the four patients in our cohort: sex, CFTR mutation status, length of P. aeruginosa infection, clinical status, forced expiratory volume (% FEV1), modulator therapy, antibiotic treatment at time of sampling, and dominant infection strain type
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | |
|---|---|---|---|---|
| Patient sex | F | F | F | M |
| CFTR mutation | F508del/R1162X | F508del/F508del | F508del/L467P | F508del/ 621 + 1G->T |
| Length of Pa infection | 15 years, 2 months | 12 years, 5 months | 10 years, 4 months | 13 years |
| Clinical status | APE outpatient | APE outpatient | Stable | APE outpatient |
| FEV1 (%) | 67.96% | 74.92% | 67.83% | 60.30% |
| Modulator therapy | None | None | None | None |
| Antibiotic treatment | Inhaled tobramycin, oral azithromycin | Inhaled tobramycin, oral trimethoprim/sulfamethoxazole | Inhaled tobramycin, inhaled aztreonam, oral azithromycin | Inhaled tobramycin, oral trimethoprim/sulfamethoxazole, oral levofloxacin |
| Dominant ST | 870 | 2,999 | 1,197 | 274 |