TABLE 1.
SR pattern of echinocandin c
| ID | Patient ID | Date collected | Anid MIC value | Cas MIC value | Mutations FKS1 | Mutations FKS2 | Treatment b |
|---|---|---|---|---|---|---|---|
| CAS10-2614_S20 | 22 | 27-Oct-10 | 0.03 | 0.03 | Mica a | ||
| CAS12-3684_S68 | 22 | 21-Nov-11 | 1 | 2 | Ser663Pro | Mica | |
| CAS13-4530_S71 | 22 | 1-Nov-12 | 4 | >16 | Ser663Pro | Mica; Flu; Ampho | |
| CAS13-4778_S42 | 22 | 13-Mar-13 | 0.5 | 0.5 | Ser663Pro | Mica; Flu; Ampho | |
| CAS13-5011_S55 | 22 | 16-Jun-13 | 2 | 8 | Ser663Pro | Mica; Flu | |
| CAS08_0572_S24 | 24 | 13-Oct-08 | 0.125 | 0.125 | Unknown | ||
| CAS08-0725_S45 | 24 | 3-Dec-08 | 1 | 0.5 | Phe659Try | Unknown | |
| CAS09_0869_S25 | 24 | 5-Jan-09 | 1 | 2 | Phe659Try | Unknown | |
| CAS11-2902_S56 | 29 | 31-Jan-11 | 0.03 | 0.06 | Mica | ||
| CAS11-2996_S80 | 29 | 4-Mar-11 | 4 | >16 | Ser663Pro | Flu; Mica | |
| CAS156404_S48 | 31 | 18-Mar-15 | 0.03 | 0.03 | Mica | ||
| CAS156677_S67 | 31 | 6-Aug-15 | 2 | 8 | Ser629Pro | None | |
| CAS08_0124_S32 | 1 | 28-May-08 | 0.03 | 0.03 | |||
| CAS12-4416_S11 | 1 | 3-Nov-12 | 2 | 2 | Ser629Pro | Flu; Mica | |
| CAS13-5111_S2 | 14 | 9-Oct-13 | 0.03 | 0.03 | Mica | ||
| CAS13-5257_S26 | 14 | 3-Dec-13 | 2 | 8 | Ser663Pro | Mica | |
| CAS14-5368_S62 | 14 | 8-Jan-14 | 2 | 8 | Ser663Pro | Ampho; Mica | |
| CAS14-5293_S38 | 21 | 24-Nov-13 | 0.06 | 0.06 | Mica; Flu | ||
| CAS14-5468_S77 | 21 | 10-Feb-14 | 2 | 4 | Phe625Ser | Mica; Flu |
a
Mica = micafungin, Flu = fluconazole, Anid= anidulafungin, Ampho = amphotericin B.
b
Patient received systemic antifungal medication to treat candidemia on or after positive culture date.
c
Presence of the main reported mutations in HS1 FKS1 and FKS2. Shaded MIC values represent resistant isolates. Patient IDs in bold font represent patients in common with SR pattern for fluconazole.