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. Author manuscript; available in PMC: 2024 Feb 14.
Published in final edited form as: Mol Cell. 2023 Jan 11;83(3):416–427. doi: 10.1016/j.molcel.2022.11.012

Figure 1. Integrator contains modules with both endonuclease and phosphatase activities.

Figure 1.

Shown are schematics depicting the balance between pause release by P-TEFb vs. Integrator-mediated termination, depicting the cleavage activity of the Integrator endonuclease, and the phosphatase activity of Integrator-associated PP2A.