Table 1.
Cytotoxicity of the tested compounds and erlotinib over MDA-MB-231 and PC-3 (IC50, µM).
| Compound | Cytotoxic activity IC50 (µM)a | |
| MDA-MB-231 | PC-3 | |
| 4a | 23.60 ± 0.36 | 10.22 ± 0.57 |
| 4b | 11.78 ± 0.98 | 8.99 ± 1.14 |
| 4c | 8.5 ± 0.85 | 37.58 ± 1.18 |
| 4d | >50 | >50 |
| 4e | 24.28 ± 2.28 | 23.13 ± 1.2 |
| 5 | 46.26 ± 2.70 | 3.56 ± 0.056 |
| 6a | >50 | >50 |
| 6b | >50 | >50 |
| 6c | >50 | >50 |
| 7 | >50 | >50 |
| 8 | >50 | >50 |
| 9a | >50 | >50 |
| 9b | >50 | >50 |
| 9c | >50 | >50 |
| 9d | >50 | >50 |
| 9e | >50 | >50 |
| Erlotinib | 11.14 ± 1.11 | 12.3 ± 0.97 |
a
IC50 values represent mean ± SD of three experiments.