Table 4.

Docking score of tested compounds representing series A, B, and C.

Compound	Docking S score (kcal/mol) EGFR tyrosine kinase (PDB ID: 1M17)	Docking S score (kcal/mol) PI3Kβ kinase (PDB ID: 4JPS)
4a	–7.2263	–7.5230
4b	–8.14	–8.2550
4c	–8.3325	–7.4893
4d	–8.203	–8.1676
4e	–8.0395	–8.1329
5	–8.5935	–8.5675
6a	–7.1866	–7.5986
6b	–7.4940	–7.8937
6c	–8.0499	–7.2646
7	–7.1135	–6.8660
8	–7.0523	–7.4376
9a	–5.9335	–6.2884
9b	–6.5485	–6.5485
9c	–6.3117	–6.2472
9d	–6.1534	–6.6562
9e	–6.5811	–7.2376
Erlotinib	–8.44	–
LY294002	–	–6.175