Figure 5.

Heritability of FC was estimated using a multidimensional heritability model (Anderson et al., 2021) using resting-state fMRI data from 778 9–10-year-olds (170 MZ pairs and 219 DZ pairs). FC between a given parcel and all other parcels in the brain was calculated at fine and coarse granularities, before and after CHA. The coarse-scale connectivity profiles aligned based on cortical anatomy are the most heritable. A, Spatial distribution of h²-multi scores before and after hyperalignment at the fine and coarse scales, as visualized on the cortical surface for each parcel. B, For both anatomically aligned and hyperaligned data, connectivity profiles are more heritable when calculated at the coarse scale than the fine scale (99.6% of the time). C, At the coarse scale, the anatomically aligned connectivity profiles are more heritable than the hyperaligned ones, but not at the fine scale, which is under comparatively minuscule genetic control. Box-and-whisker plots showing the distribution of h²-multi across parcels within connectome type. Box shows first quartile, median, and third quartile of distribution. Whiskers represent 1.5 times the interquartile range, and points represent outlier values.