Table II.
Maternal and infant characteristics of preterm neonates with and without isolated serious CHD
| Characteristics | No serious CHD (N = 234 522) | Isolated serious CHD (N = 1921) | P value |
|---|---|---|---|
| Maternal race/ethnicity, n (%) | .036 | ||
| Non-Hispanic white | 58 372 (24.9) | 481 (25.0) | |
| Hispanic | 112 753 (48.1) | 910 (47.4) | |
| Non-Hispanic black | 16 416 (7.0) | 160 (8.3) | |
| Asian | 33 554 (14.3) | 245 (12.8) | |
| Other | 13 427 (5.7) | 125 (6.5) | |
| Maternal age, y, median (IQR) | 30.0 (25.0-35.0) | 31.0 (26.0-36.0) | <.001 |
| Parity, n (%) | |||
| Multiparous | 153 044 (65.3) | 1229 (64.0) | .24 |
| Nulliparous | 81 478 (34.7) | 692 (36.0) | |
| Insurance, n (%) | |||
| Private | 112 124 (50.9) | 871 (47.9) | .013 |
| Public | 108 302 (49.1) | 946 (52.1) | |
| Maternal education, n (%) | |||
| <12 y | 41 848 (17.8) | 352 (18.3) | .46 |
| 12y | 68 362 (29.1) | 578 (30.1) | |
| >12 y | 124 312 (53.0) | 991 (51.6) | |
| Maternal obesity, n (%) | |||
| Not obese | 98 267 (63.3) | 745 (58.0) | <.001 |
| Obese | 57 037 (36.7) | 540 (42.0) | |
| Hypertensive disorders, n (%) | |||
| None | 177 213 (75.6) | 1361 (70.8) | <.001 |
| Preexisting HTN, no PE | 5730 (2.4) | 63 (3.3) | |
| Preexisting HTN and PE | 9769 (4.2) | 119 (6.2) | |
| Gestational HTN, no PE | 10 303 (4.4) | 94 (4.9) | |
| Gestational HTN and PE | 31 507 (13.4) | 284 (14.8) | |
| Diabetes, n (%) | |||
| None | 191 185 (81.5) | 1456 (75.8) | <.001 |
| Gestational diabetes | 38 066 (16.2) | 381 (19.8) | |
| Preexisting diabetes | 5271 (2.2) | 84 (4.4) | |
| Placenta previa, n (%) | |||
| No placenta previa | 225 454 (96.1) | 1865 (97.1) | .031 |
| Placenta previa | 9068 (3.9) | 56 (2.9) | |
| Amniotic fluid volume, n (%) | |||
| Normal | 221 321 (94.4) | 1696 (88.3) | <.001 |
| Oligohydramnios | 9806 (4.2) | 131 (6.8) | |
| Polyhydramnios | 3395 (1.4) | 94 (4.9) | |
| Mode of delivery, n (%) | |||
| Vaginal delivery | 110 160 (47.0) | 661 (34.4) | <.001 |
| Cesarean | 124 362 (53.0) | 1260 (65.6) | |
| Reason for preterm birth, n (%) | |||
| Preterm labor | 112 194 (50.2) | 916 (49.0) | .17 |
| PROM | 59 660 (26.7) | 487 (26.1) | |
| Provider-initiated | 51 452 (23.0) | 465 (24.9) | |
| Gestational age, wk, median (IQR) | 35.0 (34.0-36.0) | 34.0 (32.0-36.0) | <.001 |
| Sex, n (%) | |||
| Male | 126 674 (54.0) | 1068 (55.6) | .17 |
| Female | 107 848 (46.0) | 853 (44.4) | |
| Birth weight, g, median (IQR) | 2475.0 (2077.0-2830.0) | 2121.0 (1525.0-2624.0) | <.001 |
| Birth weight z-score category, n (%) | |||
| AGA | 200 085 (85.3) | 1434 (74.6) | <.001 |
| SGA | 18 079 (7.7) | 332 (17.3) | |
| LGA | 16 358 (7.0) | 155 (8.1) | |
| Gestation, n (%) | |||
| Singleton birth | 186 091 (79.3) | 1508 (78.5) | .36 |
| Multiple birth | 48 431 (20.7) | 413 (21.5) |
AGA, appropriate for gestational age; HTN, hypertension; LGA, large for gestational age; PE, preeclampsia; PROM, premature rupture of membranes; SGA, small for gestational age.