Figure 1.

Hyperhidrosis sweat cycle: (a) Daily stress induces physiological response and sympathetic nervous system becomes active, (b) sweat glands become active (glands become more active in hyperhidrosis individuals due to physiological imbalance, (c) sweat awareness makes the situation worse for hyperhidrotic sufferers, and it becomes a primary stressor, (d) primary stressor may aggravate the daily stress, due to which the sufferers get caught up in hyperhidrosis sweat cycle, (e) daily chronic stress may negatively influence the expression pattern of certain human anxiety-related genes, and (f) changes in the epigenetics may impact the normal physiological homeostasis of the sufferers by influencing the autonomic nervous system