Table 4. Systemic-organ classes of adverse drug reactions (ADRs) and the suspected medicines.
| Types of reaction | Suspected medicines* | Number of ADRs |
|---|---|---|
| Cutaneous manifestation | ||
| Erythema multiforme | Co-trimoxazole (4), Ampicillin (2), Sulfadoxine/pyrimethamine (1), Phenobarbitone (2), Cefixime (1) |
7 |
| Pustular rash | Vancomycin (4) | 4 |
| Macular and morbiliform rash | Ampicillin (1), Albendazole (1), Cefotaxime (1) |
3 |
| Stevens-Johnson syndrome | Sulfadoxine/pyrimethamine (2), Co-trimoxazole (2), Ampicillin (2) |
2 |
| Angioneurotic edema | Amodiaquine (1) | 1 |
| Systemic manifestation | ||
| Electrolyte disturbances | Prednisolone (2), Frusemide (2) |
3 |
| Red man syndrome | Vancomycin (2) | 2 |
| Anaphylactic shock | Ceftriaxone (1), Etoposide (1) |
2 |
| Hypothermia | Cefixime (1), Amodiaquine (1), Artesunate (1) |
1 |
| Tachycardia | Salbutamol (1) | 1 |
| CNS manifestation | ||
| Dystonia | Amodiaquine (1), Artesunate (1), Promethazine (1), Cefixime (1) |
2 |
| Transient loss of vision | Quinine (1) | 1 |
| Seizure | Cefixime (1) | 1 |
| Sedation | Pentazocine | 1 |
| Endocrine manifestation | ||
| Hyperglycemia | Prednisolone (1) | 1 |
| GIT manifestation | ||
| Constipation | Metronidazole (1), Amoxicillin (1), Pentazocine (1), Tramadol (1) |
3 |
| Diarrhea | Amoxicillin/clavulanic acid (1) | 1 |
| Ileus | Loperamide (1), Frusemide (1) |
2 |
| Hematological manifestation | ||
| Anemia | Carbamazepine (1) | 1 |
| Hemolysis | Co-trimoxazole (1) | 1 |
| Total | 53 | 40 |
*
more than one medicine was suspected for a single adverse reaction; CNS = central nervous system; GIT = gastrointestinal tract.