Table 5. Clinical details and characteristics of patients admitted due to adverse drug reactions and the suspected medicines (ADR).
Adverse drug reactions | Indication for the medicine | Medicine(s) used | Suspected medicine(s) | Age (years) | Sex | Severity | Duration of admission (days) |
---|---|---|---|---|---|---|---|
Dystonia | Malaria, enteric fever* | Cefixime, amodiaquine/artesunate, paracetamol | Amodiaquine, artesunate, cefixime | 12 | Male† | Moderate | 4 |
Hypothermia | Malaria, enteric fever* | Cefixime, amodiaquine/artesunate, paracetamol | Amodiaquine, artesunate, cefixime | 12 | Male† | Moderate | 4 |
Electrolyte disturbance | Status asthmaticus* | Prednisolone, salbutamol, erythromycin | Prednisolone | 6 | Female‡ | Moderate | 14 |
Hyperglycemia | Status asthmaticus* | Prednisolone, salbutamol, erythromycin | Prednisolone | 6 | Female‡ | Moderate | 14 |
Erythema multiforme | Generalized seizure* | Phenobarbitone | Phenobarbitone | 6 | Male | Severe | 8 |
Erythema multiforme | URTI, malaria§ | Sulfadoxine/pyrimethamine, co-trimoxazole, paracetamol | Sulfadoxine/pyrimethamine, co-trimoxazole | 10 | Male | Severe | 21 |
Erythema multiforme | URTI|| | Co-trimoxazole | Co-trimoxazole | 12 | Male | Severe | 28 |
Erythema multiforme | URTI|| | Co-trimoxazole, ampicillin | Co-trimoxazole, ampicillin | 8 | Female | Severe | 18 |
Erythema multiforme | URTI, malaria§ | Co-trimoxazole, chloroquine, paracetamol | Co-trimoxazole | 10 | Male | Severe | 20 |
Macular and morbiliform rash | URTI¶ | Ampicillin | Ampicillin | 2 | Female | Moderate | 7 |
Macular and morbiliform rash | Abdominal pain§ | Albendazole | Albendazole | 10 | Male | Moderate | 10 |
Ileus | Diarrhea¶ | Loperamide, co-trimoxazole, chloroquine | Loperamide | 3 | Male | Moderate | 7 |
Stevens-Johnson syndrome | Malaria, enteric fever§ | Ampicillin, co-trimoxazole, sulfadoxine/pyrimethamine, ibuprofen | Ampicillin, Co-trimoxazole, sulfadoxine/pyrimethamine | 10 | Male | Fatal | Died 10 days later |
Stevens-Johnson syndrome | Malaria, URTI§ | Ampicillin, co-trimoxazole, sulfadoxine/pyrimethamine | Ampicillin, Co-trimoxazole, sulfadoxine/pyrimethamine | 12 | Male | Fatal | Died 5 days later |
Medicine prescribed at the Lagos State University Teaching Hospital outpatient clinic;
a patient who presented with two types of suspected adverse drug reactions (dystonia and hypothermia) to more than one medicine;
a patient who presented with two types of suspected adverse drug reactions (electrolyte disturbances and hyperglycemia) to a single suspected medicine;
self-medicated medicine (medicine not prescribed by a doctor);
medicine prescribed at a primary healthcare center;
medicine prescribed by a general practitioner. URTI = upper respiratory tract infection.