Figure 1.

hm²α-SYN-39 transgenic mouse overexpress human synuclein. Slide scanning images (20× objective) of a coronal midbrain section through the substantia nigra stained for TH in green in hm²α-SYN-39 transgenic mice and wild-type (WT) mice at (A) low power (20× objective). B, Subsections from A outlined in white stained for TH in green. C, Same sections as in B stained for human synuclein in red, and (D) merged images with co-stained neurons in yellow. E, Confocal images (40× objective, 8× digital zoom) of synuclein expression in dopaminergic neurons of the substantia nigra from a wild-type mouse and an hm²α-SYN-39 transgenic mouse. Scale bars: A–D, 125 μm; E, 5 μm. F, Western blots from two hm²α-SYN-39 transgenic mice and two WT littermate controls.