Table 2. Twenty-six identified gene has not been reported to be associated with PD in previous TWAS studies.
| REGION | GENE | Type | TISSUE | PD GWAS | PDMTAG | ||||
| TWAS-P | TWAS-Z | FOCUS-pip | TWAS-P | TWAS-Z | FOCUS-pip | ||||
| 1q21.3 | EFNA3b | protein | Stomach | - | - | - | 8.28E-08 | 4.85 | 0.938 |
| 1q22 | FAM189Bb | protein | Brain_Cerebellum | - | - | - | 1.69E-08 | 5.24 | 0.948 |
| GBAab | protein | Spleen | 1.29E-08 | 6.13 | 1 | 1.37E-10 | 6.95 | 1 | |
| 2q24.3 | STK39ab | protein | Brain_Caudate_basal_ganglia | 1.13E-07 | -5.09 | 0.98 | 1.51E-07 | -5.05 | 0.976 |
| protein | Brain_Nucleus_accumbens_basal_ganglia | 1.98E-07 | -4.82 | 0.928 | 3.27E-07 | -4.77 | 0.911 | ||
| protein | Brain_Putamen_basal_ganglia | 2.91E-07 | -4.94 | 0.958 | 2.95E-07 | -4.93 | 0.958 | ||
| 3q27.1 | LAMP3b | protein | Brain_Putamen_basal_ganglia | - | - | - | 8.94E-09 | -5 | 0.914 |
| 4p15.32 | FAM200Bab | protein | Brain_Cerebellar_Hemisphere | 2.06E-09 | 6.06 | 1 | 2.65E-08 | 5.64 | 0.998 |
| 4p16.3 | DGKQab | protein | Brain_Cerebellar_Hemisphere | - | - | - | 6.42E-24 | -10.4 | 1 |
| protein | Brain_Amygdala | 4.68E-08 | -5.21 | 1 | - | - | - | ||
| protein | Brain_Hippocampus | 4.68E-08 | -5.21 | 0.997 | - | - | - | ||
| protein | Brain_Cerebellum | - | - | - | 5.60E-23 | -10 | 1 | ||
| protein | Brain_Substantia_nigra | 6.10E-12 | -5.21 | 1 | - | - | - | ||
| protein | Brain_Spinal_cord_cervical_c-1 | 4.30E-12 | -5.25 | 1 | 9.40E-09 | -5.48 | 1 | ||
| protein | Colon_Sigmoid | 9.37E-13 | -7.26 | 1 | 2.37E-19 | -8.59 | 1 | ||
| protein | Colon_Transverse | 1.09E-11 | -7.31 | 1 | 2.71E-17 | -7.92 | 1 | ||
| protein | Liver | 8.32E-13 | -7.18 | 1 | 9.35E-19 | -8.39 | 1 | ||
| protein | Pancreas | 1.25E-12 | -6.76 | 1 | 2.55E-15 | -7.78 | 1 | ||
| protein | Pituitary | 8.91E-13 | -6.14 | 1 | 1.07E-11 | -6.8 | 1 | ||
| protein | Small_Intestine_Terminal_Ileum | - | - | - | 1.12E-21 | -8.97 | 1 | ||
| protein | Spleen | 3.89E-12 | -8.19 | 1 | 6.88E-21 | -9.22 | 1 | ||
| protein | Whole_Blood | 6.03E-10 | -7.19 | 1 | 1.44E-14 | -8.03 | 1 | ||
| 4q21.1 | CDKL2ab | protein | Stomach | 3.92E-09 | 5.93 | 0.934 | 3.59E-09 | 6.05 | 0.957 |
| 5q12.1 | NDUFAF2ab | protein | Brain_Cortex | 1.11E-08 | 5.5 | 0.996 | 4.41E-09 | 5.65 | 0.998 |
| protein | Brain_Hippocampus | 1.30E-08 | 5.46 | 0.997 | 5.27E-09 | 5.6 | 0.999 | ||
| protein | Brain_Nucleus_accumbens_basal_ganglia | 6.97E-09 | 5.6 | 0.999 | 2.75E-09 | 5.75 | 0.999 | ||
| protein | Brain_Putamen_basal_ganglia | 4.95E-09 | 5.68 | 0.999 | 1.92E-09 | 5.83 | 1 | ||
| protein | Brain_Substantia_nigra | 2.15E-08 | 5.34 | 0.994 | 8.93E-09 | 5.48 | 0.997 | ||
| protein | Pancreas | - | - | - | 1.90E-07 | 5.67 | 0.994 | ||
| 6p21.32 | HLA-DQB1b | protein | Brain_Cortex | - | - | - | 1.49E-06 | -4.77 | 0.909 |
| protein | Stomach | - | - | - | 1.49E-06 | -4.77 | 0.911 | ||
| 11q25 | IGSF9Bb | protein | Brain_Cerebellar_Hemisphere | - | - | - | 2.96E-07 | -4.88 | 0.945 |
| protein | Brain_Hippocampus | - | - | - | 2.38E-07 | -4.92 | 0.954 | ||
| protein | Small_Intestine_Terminal_Ileum | - | - | - | 4.18E-07 | -4.82 | 0.927 | ||
| 12q24.31 | CCDC62ab | protein | Brain_Cerebellar_Hemisphere | 2.10E-08 | 5.76 | 0.999 | 1.11E-09 | 5.64 | 0.999 |
| protein | Brain_Cerebellum | - | - | - | 4.98E-09 | 5.41 | 0.996 | ||
| 16p11.2 | FBXL19b | protein | Brain_Substantia_nigra | - | - | - | 1.17E-10 | -6.18 | 0.966 |
| 17p12 | TTC19a | protein | Whole_Blood | 3.13E-07 | -4.88 | 0.924 | - | - | - |
| 17p12 | ADORA2Bb | protein | Brain_Substantia_nigra | - | - | - | 8.42E-08 | 5.04 | 0.969 |
| protein | Colon_Transverse | - | - | - | 1.31E-07 | 5 | 0.964 | ||
| 17q21.31 | ARHGAP27ab | protein | Brain_Caudate_basal_ganglia | 1.10E-19 | -9.26 | 1 | 1.75E-20 | -9.53 | 0.985 |
| 17q21.32 | CRHR1a | protein | Colon_Sigmoid | 1.50E-21 | -9.38 | 0.971 | - | - | - |
| 17q21.32 | WNT3ab | protein | Colon_Transverse | 8.50E-20 | -8.51 | 0.962 | 1.48E-21 | -8.8 | 0.985 |
| protein | Whole_Blood | 5.73E-16 | -6.89 | 1 | - | - | - | ||
| 3q27.1 | MCCC1-AS1ab | lncRNA | Brain_Cerebellar_Hemisphere | 2.36E-07 | -4.1 | 0.937 | - | - | - |
| lncRNA | Brain_Cortex | 5.80E-08 | -4.71 | 0.963 | 6.13E-07 | -4.12 | 0.915 | ||
| lncRNA | Brain_Frontal_Cortex_BA9 | 8.33E-08 | -4.57 | 0.995 | - | - | - | ||
| lncRNA | Brain_Nucleus_accumbens_basal_ganglia | 8.67E-08 | -4.56 | 0.947 | - | - | - | ||
| 4q22.1 | SNCA-AS1b | lncRNA | Brain_Cerebellar_Hemisphere | - | - | - | 3.13E-06 | -5.32 | 0.944 |
| 7p15.3 | KLHL7-DTb | lncRNA | Brain_Cerebellum | - | - | - | 2.75E-07 | -4.79 | 0.919 |
| 17q21.31 | MAPT-IT1b | lncRNA | Brain_Substantia_nigra | - | - | - | 1.93E-22 | -9.63 | 0.963 |
| 17q21.31 | KANSL1-AS1b | lncRNA | Brain_Spinal_cord_cervical_c-1 | - | - | - | 5.00E-23 | -9.68 | 0.981 |
| lncRNA | Liver | - | - | - | 6.67E-21 | -9.24 | 0.992 | ||
| 17q21.31 | CR936218.1a | lncRNA | Stomach | 3.87E-20 | 9.03 | 0.996 | - | - | - |
| 17q21.32 | CR936218.2a | lncRNA | Liver | 7.73E-21 | 8.21 | 1 | - | - | - |
| MAPT-AS1a | lncRNA | Brain_Amygdala | 4.51E-08 | 9.38 | 0.944 | - | - | - | |
aThe posterior probabilities of FOCUS >0.9 only in PD GWAS.
bThe posterior probabilities of FOCUS >0.9 only in PD MTAG.
abthe posterior probabilities of FOCUS >0.9 both in PD GWAS and PD MTAG.