Figure 2.

Regional disorder is distinct from Shannon’s entropy and age-associated changes in mean methylation. (A) The relationship of regional entropy (RE; black line) with regional methylation and regional disorder (RD; blue dots) with regional methylation (RM). Data points show a single region averaged across all samples. (B) Relationship between RD and RE averaged across all samples. (C) Correlation coefficients of RD with age and RM with age across the 153 samples used to build the epigenetic clock. Regions which increase in RM or RD with age have positive correlation coefficients, regions which decrease in RM or RD with age have negative correlation coefficients.