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. 2024 Jan 4;134(4):e173002. doi: 10.1172/JCI173002

Figure 5. Female Aster-B–KO mice have decreased energy expenditure.

Figure 5

(A) Cumulative food consumed per mouse from female WT versus Aster-B–KO mice fed with WD for 4 weeks; n = 10 WT and 12 Aster-B–KO mice. (B) Body weight measures from (A); n = 10 WT and 12 Aster-B–KO mice. (C) Energy expenditure measured by indirect calorimetry in mice after 4 weeks on WD; n = 9 WT and 11 Aster-B–KO mice. (D) Locomotor activity as measured when a mouse crossed multiple infrared beams during the calorimetry experiment; n = 9 WT and 11 Aster-B–KO mice. (E and F) Expression levels of the indicated genes in the sWAT (E) and liver (F) of WT and Aster-B–KO mice. n = 10 WT and 14 Aster-B–KO mice for sWAT; n = 10 WT and 10 Aster-B–KO mice for liver. All data are presented as mean ± SEM. P values were determined by 2-way ANOVA (A–D) or 2-sided Student’s t-test (E and F). *P < 0.05, **P < 0.01, *****P < 0.00001.