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. 2023 Dec 19;134(4):e174138. doi: 10.1172/JCI174138

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© 2023 Raymundo et al.

This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Volcano plot of RNA-Seq data from back skin of P4 control mice compared with K14Cre⁺Kctd1^fl/flKctd15^fl/fl mice. (B) Heatmap shows expression of selected differentially expressed genes (DEGs) in the back skin of P4 control mice compared with K14Cre⁺Kctd1^fl/flKctd15^fl/fl mice. Upregulated DEGs in the skin of K14Cre⁺Kctd1^fl/flKctd15^fl/fl mice include Krt16, Foxi3, and Stfa2 (arrows). (C) Venn diagrams show DEGs in P4 back skin or 3-week-old back skin epidermis of K14Cre⁺Kctd1^fl/flKctd15^fl/fl mice (compared with K14Cre⁺Kctd15^fl/fl mice that did not have hair/skin abnormalities). Among DEGs upregulated at both time points examined are Foxi3, Krt16, and Stfa2. (D) Gene Ontology (GO) enrichment analysis of P4 back skin RNA-Seq data from K14Cre⁺Kctd1^fl/flKctd15^fl/fl mice versus control littermates. (E) GSEA shows downregulated pathways in the back skin of P4 K14Cre⁺Kctd1^fl/flKctd15^fl/fl mice, as well as in the back skin epidermis of 3-week-old K14Cre⁺Kctd1^fl/flKctd15^fl/fl mice compared with K14Cre⁺Kctd15^fl/fl mice. NES, normalized enrichment score.