FIG. 2.

Transmission electron micrographs demonstrating P. gingivalis invasion of EC. (A and B) BAEC with P. gingivalis A7436. (A) At the cell surface, bacteria appear to induce EC structural rearrangements consistent with an endocytic mechanism. (B) Internalized bacteria are found within vacuole. (C) BAEC with P. gingivalis 381. Note the apparent contact between microfilamentous cellular components and surface-adhering P. gingivalis. (D) BAEC with P. gingivalis fimA mutant DPG3. Absence of intimate interaction between EC surface and bacteria. (E and F) FBHEC incubated with P. gingivalis A7436. Surface adherence (E) and engulfment in vacuole (F). Arrows in all panels point to P. gingivalis. Bars on each image are 0.5 μm unless otherwise specified. Composite image was constructed with Adobe Photoshop 3.0.