Fig. 7. FOXO1 and lipid metabolism genes are commonly upregulated across dormant adult cells.
a, PC analysis of nine publicly available datasets comparing gene expression signatures of quiescent/dormant versus activated cells (n = 2–7 replicates per condition per cell type). Conditions are indicated by the different colours. b, Heatmap displaying all genes with a P < 0.05 (as found by DESeq), subdivided into stem cell type-specific expression or common genes defined as those upregulated or downregulated in at least four out of six cell types. Zoom-in heatmap for the expression of FOXO1, SLC22A5, LIPE, LIPN1, PSAP, ACP2, PITPNC1, STARD5, PPT2, MTM1 and LIPA. c, GO analysis of commonly upregulated and downregulated genes in dormant stem cells compared with proliferating stem cells. The Benjamini–Hochberg correction was used. P value cutoff: 0.05, q value cutoff: 0.1. A full list of GO terms is provided in Supplementary Table 10. d, Model of carnitine/FOXO1-enhanced developmental pausing through balanced FAO and the establishment of a deeper dormant state.