Table 1.

Studies reporting on genetic testing yield with use of the Exeter MODY probability calculator (EMPC)

Study	Country	Participants	Monogenic diabetes type(s) assessed	Outcome
Thomas [19]	UK	36 adult probands (four non-White Europeans) referred for monogenic diabetes testing	MODY and mitochondrial DM	20% EMPC cutoff → 50% PPV
Ang [20]	Singapore	71 multiethnic Asian adults (59 Chinese, 14 Malay and 11 Indian) preselected on features, ( e.g., pancreatic autoantibody status) to exclude obvious T1DM and T2DM	MODY, monogenic insulin resistance and lipodystrophy	62% EMPC cutoff → 30% PPV
Haliloglu [21]	Turkey	54 Turkish children preselected by criteria including pancreatic autoantibody status	MODY	75% EMPC cutoff + additional features, e.g. HbA1c → 57% PPV
Davis [7]	Australia	25 Australians of mixed ethnicities recruited by various means, e.g., advertising	MODY, NDM	25% EMPC cutoff → 28% PPV
Tarantino [22]	Brazil	34 Brazilian probands with previous clinical diagnosis of monogenic diabetes	GCK-MODY and HNF1A-MODY	50% EMPC cutoff → 48% PPV; 75% EMPC cutoff → 53% PPV
Lee [23]	Korea	40 Korean probands preselected by criteria including pancreatic autoantibody status	MODY, NDM and lipodystrophy	50% EMPC cutoff → 15% PPV
Da Silva Santos [24]	Portugal	73 Portuguese probands preselected by criteria including pancreatic autoantibody status	All monogenic diabetes	25% EMPC cutoff → 65% PPV; newly derived 36% EMPC cutoff → 74% PPV

PPV positive predictive value (i.e. mutation detection rate), T1DM type 1 diabetes mellitus and T2DM type 2 diabetes mellitus