Table 4.

Performance of the Exeter MODY probability calculator according to final genetic status

	EMPC ≥ 10% cutoff (%)	EMPC ≥ 25% cutoff (%)	EMPC ≥ 40% cutoff (%)	EMPC ≥ 60% cutoff (%)
Sensitivity	100	78	67	33
Specificity	18	45	55	68
PPV	33	37	38	30
NPV	100	83	80	71

Positive cases were those with likely pathogenic/pathogenic variants whereas all others were deemed negative for the purpose of assessing EMPC performance

EMPC Exeter MODY probability calculator, NPV negative predictive value and PPV positive predictive value