Table 3.

Prognostic factors for recurrence-free survival in 8 AFP-H patients.

	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
Lauren classification
Diffuse	Ref
Intestinal	1.130 (0.668–1.912)	0.6494	–
Lymphatic invasion
No	Ref		Ref
Yes	5.805 (3.006–11.21)	< 0.0001	0.846 (0.368–1.944)	0.6931
Vessel invasion
No	Ref		Ref
Yes	7.309 (3.585–14.90)	< 0.0001	1.976 (0.855–4.566)	0.1109
AFP*
AFP-N	Ref		Ref
AFP-H	9.816 (3.885–24.80)	< 0.0001	3.693 (1.410–9.674)	0.0078
CEA
< 5	Ref		Ref
5 =  <	2.860 (1.620–5.049)	0.0003	1.295 (0.720–2.329)	0.3878
CA19-9
< 37	Ref		Ref
37 =  <	3.743 (1.889–7.416)	0.0002	2.410 (1.185–4.904)	0.0152
Stage
I	Ref		Ref
II	11.67 (4.563–30.09)	< 0.0001	7.628 (2.589–22.40)	0.0002
III	27.85 (11.72–66.20)	< 0.0001	17.92 (6.151–52.23)	< 0.0001

Univariate and multivariate analyses revealed that preoperative serum AFP levels were significantly associated with OS and RFS.

*Preoperative serum AFP.