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. 2024 Feb 14;9:40. doi: 10.1038/s41392-024-01748-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Identification of aptamers of SARS-CoV-2 N protein with high neutralization activity. a Schematic diagram of magnetic bead screening aptamers. b The retention rate of five rounds of screening aptamers using SARS-CoV-2 NP. c Detection of library affinity using SPR (Surface plasmon resonance). d Preliminary screening of the antiviral effects of 165 aptamers against authentic SARS-CoV-2, 6 of 165 aptamers were selected for further evaluation. e The screening details and sequences of 6 selected aptamers. f The secondary structures of six aptamers using NUPACK software