Table 6.

Regression model outputs in PD: CSF biomarkers (pg/mL).

Model		a-Synuclein (a-syn)				Amyloid-b				CSF p-tau (2016 assay)
		PD	PD-F	PD-M	PD-M*	PD	PD-F	PD-M	PD-M*	PD	PD-F	PD-M	PD-M*
R2		0.092	0.234	0.033	0.034	0.045	0.089	0.028	0.020	0.08	0.11	0.07	0.06
F (p-value†)		6.091 (<0.001)	9.350 (<0.001)	1.540 (0.219)	1.062 (0.399)	2.746 (0.018)	2.882 (0.034)	1.645 (0.191)	0.612 (0.663)	4.824 (<0.001)	3.603 (0.013)	4.085 (0.005)	1.668 (0.191)
Brain-PAD	b	−15.45	−32.68	−8.89	−10.69	−10.39	−19.479	−6.897	−7.799	−0.050	−0.160	−0.015	0.049
	t	−3.117	−3.644	−1.517	−1.251	−3.280	−2.890	−2.010	−1.505	−1.206	−1.753	−0.328	0.707
	p	0.002	<0.001	0.131	0.213	0.001	0.005	0.046	0.135	0.229	0.082	0.743	0.481
Actual age	b	10.51	15.43	8.042	5.669	0.577	0.849	0.651	−0.097	0.135	0.168	0.122	0.101
	t	2.988	2.624	1.866	0.977	0.256	0.190	0.259	−0.028	4.684	2.893	3.837	2.126
	p	0.003	0.010	0.063	0.331	0.798	0.850	0.796	0.978	<0.001	0.005	<0.001	0.035
Duration	b	12.13	27.21	0.624	11.672	0.944	9.153	−4.865	−1.162	0.024	0.106	−0.047	0.058
	t	2.330	3.580	0.090	1.238	0.283	1.583	−1.204	−0.203	0.565	1.501	−0.903	0.523
	p	0.020	<0.001	0.928	0.218	0.777	0.116	0.230	0.839	0.573	0.136	0.368	0.601
Education	b	−3.129	4.472	−6.392	−13.122	−4.139	5.271	−9.018	−5.135	0.067	0.050	0.080	0.110
	t	−0.262	0.227	−0.433	−0.697	−0.544	0.355	−1.051	−0.452	0.696	0.269	0.736	0.676
	p	0.794	0.821	0.666	0.487	0.587	0.723	0.294	0.652	0.487	0.789	0.462	0.500
Sex	b	106.4	–	–	–	26.29	–	–	–	0.543	–	–	–
	t	1.466	–	–	–	0.564	–	–	–	0.922	–	–	–
	p	0.144	–	–	–	0.573	–	–	–	0.357	–	–	–

PD Parkinson’s disease, F females, M males, M* matched males. Significant results are highlighted in bold. ^†The p-values of the F-statistics were adjusted for multiple comparisons using the FDR technique.