Table 1.
Plasma lipid profile (mg/dl), adipocyte hormones (µg/L), nitric oxide (µmol/ml) levels and blood pressure (mmHg) of obese rats treated with zinc oxide nanoparticles.
| Parameter | Treatment | |||
|---|---|---|---|---|
| Control | Obese | O + ZnONPs 5 mg/kg | O + ZnONPs 10 mg/kg | |
| Cholesterol | 90.63 ± 2.76 | 197.60 ± 4.97* | 131.50 ± 2.77*@ | 87.13 ± 6.58@# |
| Triglycerides | 66.88 ± 1.66 | 231.50 ± 13.63* | 200.50 ± 14.47* | 168.60 ± 12.86*@ |
| HDL | 37.57 ± 2.28 | 12.00 ± 0.54* | 28.13 ± 2.35*@ | 40.00 ± 2.41@# |
| LDL | 21.88 ± 1.27 | 87.38 ± 1.90* | 43.63 ± 2.21*@ | 25.25 ± 0.88@# |
| Atherogenic index | 0.26 ± 0.02 | 1.31 ± 0.03* | 0.87 ± 0.02*@ | 0.66 ± 0.04*@# |
| Leptin | 1.87 ± 0.15 | 3.11 ± 0.15* | 2.19 ± 0.25*@ | 1.94 ± 0.19@# |
| Adiponectin | 196 ± 10.31 | 51.13 ± 1.49* | 151.88 ± 8.33*@ | 188.13 ± 8.80@# |
| Nitric oxide | 40.80 ± 1.16 | 17.88 ± 0.78* | 26.00 ± 1.05* | 38.50 ± 1.68@# |
| Systolic BP | 117.87 ± 2.13 | 145.76 ± 2.95* | 130.38 ± 1.06*@ | 121.62 ± 1.89 @ |
| Diastolic BP | 81.13 ± 1.62 | 102.50 ± 2.60* | 88.38 ± 1.44@ | 80.75 ± 2.23@ |
Each value represents the mean of 8 animals ± SE. Statistical analysis was performed using one-way ANOVA followed by Tukey–Kramer multiple comparisons test (*vs control group, @vs obese group and #vs ZnONPs 5 mg/kg) at p < 0.05. O: Obese.