Fig. 2.

Modulation of inflammation by adipose tissue types. White adipose tissue predominantly secretes adipokines from adipocytes in lean subjects, while pro-inflammatory cytokines are secreted from macrophages, neutrophils, and activated T-cells in adipose tissue in obese persons. Adipose tissue in lean supports angiogenesis, insulin sensitivity, and anti-inflammation, while adipose tissue dysfunction is reported in obese subjects. IFN interferon, IL interleukin, TNF tumor necrotic factor, FABP4 fatty acid binding protein4, Th1 type 1 T helper cells, MCP-1 monocyte chemoattractant protein-1