Figure 2.

A variety of gut microbiota can affect the efficacy of immunotherapy for NSCLC through multiple immune mechanisms, such as Bifidobacteria, Bifidobacterium longum, Bifidobacterium breve, LGG, AKK, Enterococcus bacteriophage, Nissle 1917. AKK, Akkermansia muciniphila; LGG, Lactobacillus rhamnosus GG; TNFα, tumor necrosis factor alpha; KbSIY, a model neoantigen, SIYRYYGL; CRISPR/Cas9, clustered regularly interspaced short palindromic repeat; ROS, reactive oxygen species; ICD, immunogenic cell death; IDO1, indolea-mine 2,3-dioxygenase-1; TMP1, the epitope-tail length measurement protein 1; PSMβ-4, proteasome subunit beta-4.