FIGURE 11.

Plasma membrane damage to trigger Ca²⁺ overload. (A) Schematic diagram of the preparation process of CMA‐nPS and (B) their capacity to generate abundant ROS and introduce intracellular Ca²⁺ overload for enhanced antitumour efficiency. (C) Fluorescent images to detect cell membrane integrity and (D) intracellular Ca²⁺ concentration. (E) TEM images of H1299 cells after different treatments to observe mitochondrial integrity. (F) H&E and TUNEL staining images of H1299 tumour‐bearing mice after different treatments. Reproduced with permission.^{[ 79 ]} Copyright 2022, John Wiley & Sons.