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Ca2+ regulation of macrophage M1 polarization. (A) Schematic illustration of the synthesis of OMV@CaP. (B) Ca2+ release profile at different pH values. (C) pH value changes inside tumour tissues after different treatments. (D) Macrophage polarization analysis by flow cytometry. Intratumoural (E) IL‐12, (F) IL‐6, (G) TNF‐α, and (H) IFN‐γ expression were examined by ELISA. Reproduced with permission.[ 123 ] Copyright 2020, John Wiley & Sons.
