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Neutrophil migration in response to rCXCL8 and CXCL8 mutants. a) The CXCL8 mutants (R68A-CXCL8 and K64A/K67A/R68A-CXCL8: TM-CXCL8) recruited more neutrophils into the lungs than recombinant CXCL8 (rCXCL8). b) The CXCL8 mutants appeared more rapidly in plasma after intratracheal instillation than rCXCL8.
*: p < 0.05 vs rCXCL8. #: p < 0.05 vs control.
