TABLE 1.
Function of serotonin receptors in GI tract.
| Receptor | Function in GI | Reference |
|---|---|---|
| 5‐HT1 | Gastric fundus relaxation | Guzel and Mirowska‐Guzel (2022) |
| Contraction of intestinal circular muscle | Fujii et al. (2020) | |
| Contraction of intestinal longitudinal muscle | Gwynne and Bornstein (2019) | |
| Prokinetic intestinal stimulation | Legan et al. (2022) | |
| Peristaltic and secretory reflexes | Brown and Liu (2021) | |
| 5‐HT2 | Contraction of smooth muscles | Guevara and Trejo (2021) |
| Contraction of smooth muscles in stomach fundus | Li, Wang, et al. (2019) | |
| Relaxation of longitudinal muscle in the intestine | Tonini and De Ponti (2020) | |
| 5‐HT3 | Chloride secretion and serotonin release from EC cells | Spencer and Keating (2022) |
| 5‐HT4 | Increase intestinal motility | Shokrollahi et al. (2019) |
| Relaxation of colon | Li, Wang, et al. (2019) |