Table 2.

Cox proportional hazard modeling of the effect of viral load kinetics on graft survival adjusted for other risk factors.

	Unadjusted models		Adjusted AUC model		Adjusted viral load model		Adjusted duration model
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Individual AUC	1.475 (1.096, 1.987)	0.0104	1.503 (1.052, 2.147)	0.0252
CMV viral load	1.505 (1.069, 2.117)	0.0190			1.557 (1.049, 2.311)	0.0281
Duration of CMV episode	1.164 (1.039, 1.304)	0.0088					1.170 (1.022, 1.339)	0.0225
CMV D/R status at transplant
D−/R−	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
D−/R+	0.203 (0.048, 0.862)	0.0307	0.161 (0.038, 0.686)	0.0135	0.162 (0.038, 0.689)	0.0137	0.160 (0.038, 0.680)	0.0130
D+/R−	0.970 (0.523, 1.798)	0.9233	1.126 (0.563, 2.254)	0.7365	0.968 (0.458, 2.047)	0.9323	1.131 (0.568, 2.251)	0.7256
D+/R+	Reference
Induction ATG
Yes	2.299 (1.253, 4.218)	0.0072	2.217 (1.185, 4.150)	0.0128	2.225 (1.186, 4.176)	0.0127	2.140 (1.141, 4.013)	0.0177
No	Reference
Delayed graft function
Yes	2.513 (1.366, 4.624)	0.0031	2.700 (1.422, 5.126)	0.0024	2.663 (1.403, 5.055)	0.0027	2.694 (1.422, 5.105)	0.0024
No	Reference

AUC units are 100 (log₁₀ IU/mL)*days. Viral load units are log₁₀ IU/mL. Duration units are weeks.

ATG, antithymocyte globulin; AUC, area under the curve; CI, confidence interval; CMV, cytomegalovirus; D, donor; HR, hazard ratio; N/A, not applicable; R, recipient.