Figure 1.

Deleting Ahr in β-cells caused hypoglycemia in females and increased body weight in males under baseline condition. Mice were 6–12 weeks old when tracking was started. All tracking data was collected prior to chemical administration. (A,D) Body weight, (B,E) fasted blood glucose, and (C,F) fasted plasma insulin in (A–C) female and (D–F) male βAhr^WT and βAhr^KO mice. All data are presented as mean ± SEM. Individual data points on bar graphs represent biological replicates (different mice). ∗p ≤ 0.05. The following statistical tests were used: (A–F) two-tailed unpaired t-test at each individual time point.