Figure 3.

Deletion of Ahr in β-cells protected female and male mice from TCDD-induced changes in glycemia. Glucose tolerance tests were performed at (A,B,G,H) 1-week, (C,D,I,J) 4 weeks, and (E,F,K,L) 6 weeks post CO or TCDD injection (see Figure 2A for study timeline). Data is presented as a line graph and area under the curve. Line graphs are presented as (i) all treatment groups, (ii) βAhr^WT/TCDD vs βAhr^WT/CO, and (iii) βAhr^KO/TCDD vs βAhr^KO/CO. All data are presented as mean ± SEM. Individual data points in bar graphs represent biological replicates (different mice; n = 4–13 mice/group). Stats legend (p ≤ 0.05): #, βAhr^WT/TCDD vs βAhr^WT/CO; ‡, βAhr^KO/TCDD vs βAhr^KO/CO; Ꝋ, βAhr^KO/CO vs βAhr^WT/CO; †, βAhr^KO/TCDD vs βAhr^KO/TCDD. The following statistical tests were used: line graph, two-way RM ANOVA with uncorrected Fisher's LSD test; bar graphs, two-way ANOVA with Tukey's multiple comparison test.