Table 4.

Summary of the effects of an increase in the respective variable on the VAS fatigue rating

Variable			Effect on VAS rating
			Co	MS I	MS II
time of day			$╱$		$╱$
time spent awake				$╱$
sleep duration				$╲$
HR	6h:	mean	$╱$
	6h:	sd		$╱$
	as:	mean			$╱$
	as:	sd	$╲$
	as:	slope	$╲$	$╱$
SD1	3h:	min			$╲$
	3h:	mean			$╱$
	aw:	mean	$╲$
	aw:	slope	$╲$		$╱$
	as:	mean	$╲$
	as:	sd	$╱$
SD2	3h:	min	$╲$
	aw:	sd		$╱$
	aw:	slope			$╲$
	as:	min	$╱$
	as:	sd			$╱$
SDNN	1h:	sd			$╱$
	3h:	slope	$╱$
	6h:	mean	$╱$
	aw:	max		$╲$
	as:	min		$⌢$
	as:	max		$╱$
	as:	sd		$╲$
EDA peaks	1h:	sd			$╱$
	6h:	sd	$╲$
steps	6h:	count	$╲$	$╲$
	aw:	count			$╱$
activity	6h:	sd			$╱$
	6h:	max		$╲$
	aw:	max	$╲$	$\sim$	$╲$
	aw:	sd		$╱$
	aw:	int.	$╱$		$╱$
	as:	max		$╱$
temp	day:	mean		$╲$
	day:	min			$╲$
temp (felt)	day:	min		$╱$
dew	day:	mean	$╲$	$╲$
humidity	day:	mean			$╱$

The symbols $╱$, $╲$, $⌢$, $⌣$ and $\sim$ summarize the shape of respective partial dependence plots. ‘1h’, ‘3h’, ‘6h’, ‘aw’, and ‘as’ refer to the 5 time horizons defined in the STAR Methods section of one, three, and 6 h prior to the respective rating, and awake and asleep, respectively. Variables connected to weather were calculated across the whole day. Co = control group; MS I = MS patients with a functional ANS; MS II = MS patients with a dysfunctional ANS.