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. Author manuscript; available in PMC: 2024 Feb 15.
Published in final edited form as: Nat Cancer. 2023 Apr 10;4(5):699–715. doi: 10.1038/s43018-023-00539-6

Extended Data Fig. 6 |. HOXB13 is a positive regulator of PSMA (FOLH1).

Extended Data Fig. 6 |

a, Overexpression of WT-HOXB13 in LNCaP-shHOXB13 cells rescues FOLH1 expression while overexpression of G84E mutant-HOXB13 cannot rescue suppression of FOLH1. Data from GEO accession GSE15358516. b, Significant reduction in FOLH1 expression in LN95 (left) and 22Rv1 (right). Data from GEO accession GSE9937815. The boxes represent experimental replicates and samples with same treatment are labeled with same color. c, Bar charts of the expression levels of AR (top) and HOXB13 (bottom) in prostate tumors during progression from benign to NEPC. The bar colors represent FOLH1 levels in each sample. d, AR (top) and HOXB13 (bottom) ChIP-seq intensity in representative CRPC samples from GEO accession GSE13040850.