Table 2.

Comparison between McDonald 2010 and 2017 criteria for DIS and DIT recognition

DIS
McDonald 2010	McDonald 2017
≥ 1 T2 lesion in at least 2 of 4 areas of the CNS: - periventricular - juxtacortical - infratentorial - spinal cord Attention: when the patient has a brainstem or spinal cord syndrome, the symptomatic lesions are excluded from the criteria	≥ 1 T2 lesion in at least 2 of 4 areas of the CNS: - periventricular - juxtacortical or cortical - infratentorial - spinal cord Symptomatic and asymptomatic lesions are counted
DIT
McDonald 2010	McDonald 2017
1. A new T2 and/or gadolinium-	1. A new T2 and/or gadolinium-
enhancing lesion(s) on	enhancing lesion(s) on
follow-up MRI with comparison	follow-up MRI with comparison
to a previous MRI scan,	to a previous MRI scan,
independently on its date	independently on its date
2. Simultaneous presence	2. Simultaneous presence of
of asymptomatic gadolinium-	gadolinium-enhancing and
enhancing and non-enhancing	non-enhancing lesions at any time
lesions at any time	(symptomatic and asymptomatic
	lesions are counted)
	3. Presence of specific OGB
	in CSF in the absence of other CSF
	findings atypical of MS