Table 3.

Comparison between McDonald 2010 and 2017 criteria – summary

Clinical symptoms	Lesions with clinical evidence	Additional data required for a diagnosis of MS 2010	2017
≥ 2 clinical attacks	≥ 2	None	None
≥ 2 clinical attacks	1	DIS in MRI exam or demonstrated by next relapse with different CNS symptoms	DIS in MRI exam or demonstrated by next relapse with different CNS symptoms
1 clinical attack	≥ 2	DIT in MRI exam or demonstrated by next relapse And DIS in MRI exam or demonstrated by next relapse with different CNS symptoms	DIT in MRI exam or demonstrated by next relapse or by CSF-specific OCB And DIS in MRI exam or demonstrated by next relapse with different CNS symptoms
CIS (clinically isolated syndrome)	1	IT in MRI exam or demonstrated by next relapse or by CSF-specific OCB And DIS in MRI exam or demonstrated by next relapse with different CNS symptoms	DIT in MRI exam or demonstrated by next relapse or by CSF-specific OCB and DIS in MRI exam or demonstrated by next relapse with different CNS symptoms

Clinical attack – episode with objective syndromes of focal or multifocal demyelination in the CNS, which last at least 24 h with no symptoms of infection

CIS – clinically isolated syndrome, DIS – dissemination in space, MRI – magnetic resonance imaging, CNS – central nervous system, CFS – cerebrospinal fluid, DIT – dissemination in time, OCB – oligoclonal bands