Table 1.

Different search terms and combinations used in designing the search strategy based on PICOs^a

Population/patients	Intervention	Outcome	Study design
Inflammatory disease	Oenothera biennis	Inflammation marker	Randomized controlled trial
Inflammation	Oenothera biennis	Disease activity	Randomized clinical trial
Inflammation	Evening Primrose	Pain	RCT
Autoimmune disease	Evening, Primrose, Oil	Quality of life	Clinical Trials, Randomized
Rheumatoid arthritis	Onagraceae	Adverse effects	Trials, Randomized Clinical
Cardiovascular disease	Oenothera biennis	Cytokine level	Controlled Clinical Trials, Randomized
high blood pressure		Symptom improvement
Gastrointestinal diseases		Skin condition
Inflammatory bowel disease		Gut inflammation
obstructive pulmonary disease
COPD
Asthma
Metabolic disease
Diabetes Mellitus
Psoriasis
Eczema
Atopic dermatitis

^aThe OR Boolean operator was used between the terms in each column, while AND was used to combine the columns